What is a common side effect of mirtazapine/Remeron and trazodone?

Mirtazapine, commonly known by its brand name Remeron, and trazodone are both medications often used in the treatment of depression or anxiety disorders and are known for their sedative properties. Sedation is a common side effect associated with these two medications due to their effects on neurotransmitters in the brain.

Mirtazapine has a strong antihistaminergic effect, which contributes to its sedative properties. Similarly, trazodone is often used off-label as a sleep aid due to its ability to promote sleep. This sedation can be helpful for patients who also experience insomnia as part of their depressive symptoms, but it can also lead to drowsiness and impairment in daytime functioning.

In contrast, while dry mouth, weight gain, and insomnia can also occur with these medications, sedation is more prominently associated with their typical pharmacological effects and is a key reason why they are prescribed for sleep issues. Understanding the sedative effects of both mirtazapine and trazodone is crucial for patient care, particularly when counseling regarding medication management and potential impacts on daily activities.