What is the first-line medication treatment for depression?

The first-line medication treatment for depression is selective serotonin reuptake inhibitors (SSRIs). SSRIs are favored for their efficacy, safety profile, and tolerability compared to other classes of antidepressants. They work by increasing the levels of serotonin in the brain, which can help improve mood and alleviate symptoms of depression.

SSRIs are typically well-received by patients, with a lower risk of side effects compared to older medications, such as tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs). The broad clinical experience and extensive research supporting the use of SSRIs also contribute to their status as the preferred first-line agents in the treatment of depression. This class of medications tends to have a favorable side effect profile, which helps improve patient compliance and reduces the likelihood of discontinuation due to adverse effects.

Overall, SSRIs represent the standard initial treatment approach for individuals diagnosed with depression, owing to their overall effectiveness and lower risks associated with their use.