What type of antidepressant is bupropion classified as?

Bupropion is classified as a norepinephrine-dopamine reuptake inhibitor (NDRI). This classification indicates that bupropion primarily acts by inhibiting the reuptake of norepinephrine and dopamine in the brain, which helps improve mood and alleviate symptoms of depression.

Understanding the mechanism of bupropion reveals its unique position among antidepressants. Unlike selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), which focus on serotonin levels along with norepinephrine, bupropion does not primarily target serotonin pathways. This difference can lead to fewer sexual side effects, which can be particularly advantageous for many patients.

Recognizing the classification of antidepressants is vital in clinical practice as it guides medication selection based on patient symptoms, side effect profiles, and individual patient responses to treatment. Bupropion's distinctive action as an NDRI makes it a valuable option in the treatment of depression, especially in patients who may not respond well to other classes of antidepressants.