Which antidepressant is known to lower the seizure threshold the most?

Bupropion is known to lower the seizure threshold more significantly than other commonly used antidepressants. This is primarily due to its mechanism of action, which involves dopaminergic and noradrenergic reuptake inhibition. The risk of seizures can be increased, especially at higher doses or in individuals with predispositions such as a history of seizures or eating disorders.

Unlike other medications listed, such as fluoxetine, sertraline, and citalopram, which are selective serotonin reuptake inhibitors (SSRIs) and do not carry the same level of risk for lowering the seizure threshold, bupropion's unique pharmacological profile contributes to its potential for inducing seizures. While all antidepressants carry some level of risk, bupropion's association with seizures makes it particularly noteworthy in discussions about safety profiles in patients with seizure disorders or other risk factors.